Determination of p38α Kinase inhibitor dissociation rate constants using Microfluidic Technology

CASE STUDY:

Determination of p38α Kinase inhibitor dissociation rate constants using Microfluidic Technology

Synopsis

A continuous kinase assay was employed using Caliper mobility shift technology to evaluate dissociation rates of a select group of p38 mitogen activated protein kinase (MAPKα) inhibitors and thereby differentiate inhibitory mechanisms.

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