Posts Tagged ‘Chemistry’

LCMS/MS Bioanalytical Analysis

Sciex API 3000 HPLC/MS/MS Non-GLP Applications include Pharmacokinetic/Toxicokinetic analysis (PK/TK) Pharmacokinetic parameters calculated using WinNonlin Pharmacokinetic/Pharmacodynamic (PK/PD) Rapid discovery phase bioanalysis Tissue distribution Cassette dosing analysis In Vitro ADME Plasma/Serum/Matrix Stability Metabolic Stability (Liver microsomes, multiple species) Post translational protein modification Customized liquid chromatography – tandem mass spectrometry (HPLC/MS/MS) method development The early stages of…

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