Posts Tagged ‘Kinetics’

Biacore® Surface Plasmon Resonance

Applications include Pharmaceutical drug discovery Antibody characterization Proteomics Immunogenicity Biotherapeutic development and manufacture Life science research applications Biacore® is a surface plasmon resonance (SPR) based analytical instrument. Biacore® technology allows generation of high quality data on the interactions between proteins and other molecules, including small molecule drug candidates. These data provide insights into molecular function…

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Role of Enzyme:Inhibitor Kinetic Characterization in Predicting Pharmacodynamic Response of Irreversible Fatty Acid Amide Hydrolase (FAAH) Inhibitors

CASE STUDY: Role of Enzyme:Inhibitor Kinetic Characterization in Predicting Pharmacodynamic Response of Irreversible Fatty Acid Amide Hydrolase (FAAH) Inhibitors Synopsis To investigate the relevance of in vitro inhibitor kinetics to in vivo pharmacodynamics (PD), a simple fluorogenic assay was used to determine the kinetic constants of PF-3845, an irreversible FAAH inhibitor. The reported in vitro…

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