Case Studies

A Clinical Phosphoprotein Biomarker Assay

CASE STUDY: A Clinical Phosphoprotein Biomarker Assay Development, Validation, & Implementation Synopsis An assay was developed, validated and utilized in a clinical study to determine the activation of “Kinase 1” in human feces as a biomarker of colonic inflammation resulting from infection.

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Multiplexed Analysis of Intracellular Phosphoproteins

CASE STUDY: Multiplex Phosphoprotein Analysis Synopsis A virtual translation research and development pharmaceutical company was seeking a cell-based biomarker for their drug development program. A multiplex phosphoprotein assay was developed to assess signaling pathway modulation in human cancer cells in response to treatment with selected compounds.

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Role of Enzyme:Inhibitor Kinetic Characterization in Predicting Pharmacodynamic Response of Irreversible Fatty Acid Amide Hydrolase (FAAH) Inhibitors

CASE STUDY: Role of Enzyme:Inhibitor Kinetic Characterization in Predicting Pharmacodynamic Response of Irreversible Fatty Acid Amide Hydrolase (FAAH) Inhibitors Synopsis To investigate the relevance of in vitro inhibitor kinetics to in vivo pharmacodynamics (PD), a simple fluorogenic assay was used to determine the kinetic constants of PF-3845, an irreversible FAAH inhibitor. The reported in vitro…

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